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01 The main objective of this doctoral thesis is to show the influence that the development of biology had on philosophy at the dawn of Modernity, and especially on G.W. Leibniz. I contend that a correct understanding of his philosophical thought cannot be reached without taking into account the influence it received from the life sciences. I also try to test this interpretive key with some of the central concepts of Leibnizian thought. The thesis deals with biology and metaphysics at the dawn of Modernity. I believe that biology profoundly marked the development of metaphysics at the beginning of Modernity. This was the case for many authors, for example, the Van Helmont or Diderot, but the most obvious and influential case was that of Leibniz, whom we will deal with in more detail throughout the work. Although Leibniz has to be interpreted in the context of a time, his, in which this influence of biology on metaphysics occurred in a generalized way, we cannot help but contemplate and occupy ourselves with the dominant position in the XVII-XVIII centuries: Cartesian Mechanism. We wanted to do in this research work a resignification and reinterpretation of Leibniz from a vitalist approach, collecting that other biologist and doctor Leibniz, in constant debate with numerous philosophers of the moment, followers of more mechanistic positions. The subject of this doctoral dissertation is based on the work developed in the doctoral dissertation on this subject as well, which I entitled: G.W. Leibniz: from biology to metaphysics.